For laboratory research use only · Not for human consumption
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RECOVERY

TB-500

5mg
$50.00
TB-500 5mg product photograph
1
6 available · Ships within 48 hours
  • Third-Party Tested
  • Cold-Chain Handled
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Thymosin Beta-4 (1-4) fragment. Referenced in published literature investigating actin-sequestering activity, angiogenic signaling, and extracellular matrix cellular mechanisms.

  • Mitochondrial biology research
  • Cellular bioenergetics
  • Cold-chain handled, third-party tested
VIEW BATCH COA
Independent lab verification · current batch
  • THIRD-PARTY TESTED
  • COLD-CHAIN HANDLED
  • TRACKED SHIPPING
  • QUALITY-FOCUSED SOURCING
SPECIFICATIONS
Product
TB-500
Strength
5mg
Vial Size
5mg per vial
SKU
VLR-TB5-5
Batch / Lot
Current batch listed on COA
Storage
Refrigerate 2–8°C · protect from light
Form
Lyophilized powder
RESEARCH USE ONLY

Sold strictly for laboratory and research purposes — never for human consumption, food, drug, or cosmetic use. 21+ only. A standard we hold ourselves to, not just the law.

EDUCATIONAL OVERVIEW

About this compound

Context, not noise — what the research actually says.

WHAT IT IS

A research compound investigated in mitochondrial biology and cellular bioenergetics literature.

RECOVERY
KEY BENEFITS
  • Studied in cellular bioenergetic pathways
  • Investigated in oxidative-balance literature
  • Referenced in sirtuin and cellular-signaling research
COMMON USES
  • Mitochondrial biology research
  • Cellular bioenergetics studies
  • Foundational layer across the catalog
THINGS TO KNOW
  • Lyophilized — requires reconstitution with BAC water
  • Refrigerate; protect from light
  • Research use only — not for human consumption
RELATED COLLECTION
Glow Research Collection

Pairs with GHK-Cu + BPC-157A three-vial collection assembled around connective tissue biology and extracellular matrix research.

VIEW COLLECTION
COLLECTION PRICE
$119.00
STORAGE

Cold-chain handling

REFRIGERATED
Store unopened at 36–46°F (2–8°C).
RECONSTITUTED
Keep refrigerated. Do not freeze.
PROTECT FROM LIGHT
Original packaging until use.

Store unopened vials refrigerated at 36–46°F (2–8°C). After reconstitution, keep refrigerated and use within the timeframe specified by your laboratory practice. Protect from light. Do not freeze reconstituted solution.

SHIPPING

Shipping information

Insulated, tracked, and handled with care from our facility to yours.

PROCESSING
Ships within 48 hours of order confirmation.
COLD-CHAIN
Insulated packaging with ice packs for temperature-sensitive compounds.
TRACKED & INSURED
Tracking provided. Domestic delivery typically 2–5 business days.

Local pickup is available by appointment for customers in the Phoenix, Arizona area. See the full shipping policy for details, accepted payment methods, and scheduling.

FAQ

Common questions

SCIENTIFIC RESEARCH OVERVIEW · SRO

Scientific Research Overview

A structured summary of published scientific literature on this compound — provided for educational reference only.

Regenerative Research
RESEARCH SNAPSHOT
Research Category
Investigational thymosin-β4-derived pentapeptide
Biological Targets
  • Actin Dynamics
  • Cell Migration
  • Tissue Repair Pathways
Primary Areas of Research
Actin cytoskeleton dynamics · Cellular migration and motility · Angiogenesis and vascular remodeling · Extracellular-matrix organization · Wound-healing and tissue-repair models · Anti-inflammatory and cytoprotective mechanisms
Current Stage of Research
Primarily Preclinical Research
WHAT IS TB-500 (THYMOSIN Β4 FRAGMENT)?

TB-500 (research designation for an acetylated N-terminal fragment of Thymosin β4) is a synthetic pentapeptide investigated in the scientific literature across cellular-migration, tissue-remodeling, and wound-healing research. Thymosin β4 is a naturally occurring 43-amino-acid peptide, and TB-500 corresponds to its principal active region (amino acids 1–4, with an added serine residue, Ac-SDKP-Ser). Current evidence is predominantly derived from in vitro and animal studies, with no approved human drug formulation at this time.

PRIMARY AREAS OF RESEARCH
  • Actin cytoskeleton dynamics
  • Cellular migration and motility
  • Angiogenesis and vascular remodeling
  • Extracellular-matrix organization
  • Wound-healing and tissue-repair models
  • Anti-inflammatory and cytoprotective mechanisms

  • Published studies have investigated the actin-sequestering properties of Thymosin β4 and its N-terminal fragments, including their effects on G-actin/F-actin equilibrium and cellular migration.
  • Research suggests that Thymosin β4 and related fragments support endothelial-cell migration, angiogenesis, and wound-closure kinetics in preclinical models.
  • Current evidence indicates modulation of extracellular-matrix remodeling and modulation of inflammatory mediator expression in published cell-culture and animal studies.
  • Investigators have observed cytoprotective and tissue-repair activity in models of dermal, ocular, cardiac, and musculoskeletal injury in preclinical literature.

TB-500 is being studied as a fragment that retains the actin-binding and cell-migration properties associated with full-length Thymosin β4. Current evidence indicates sequestration of monomeric G-actin, which influences actin polymerization and cytoskeletal remodeling required for cell motility. Published work also suggests upregulation of vascular endothelial growth factor and matrix metalloproteinase activity, supporting angiogenesis and extracellular-matrix turnover. The precise receptor-level target remains under investigation, and human pharmacokinetic and safety data are limited.
CURRENT AREAS OF INVESTIGATION
  • Tissue Regeneration
  • Cellular Repair
  • Cell Migration
  • Angiogenesis
  • Recovery
  • Extracellular Matrix

  1. Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. View source
  2. Bock-Marquette I, Saxena A, White MD, et al. Thymosin β4 activates integrin-linked kinase and promotes adult cardiac tissue repair. Nature. 2004;432(7016):466-472. View source
  3. Philp D, Badamchian M, Scheremeta B, et al. Thymosin β4 promotes wound repair. Ann N Y Acad Sci. 2003;1002:362-370. View source
  4. Sosne G, Chan CC, Thai K, et al. Thymosin β4 promotes corneal wound healing and modulates inflammatory mediators. Invest Ophthalmol Vis Sci. 2001;42(6):1303-1308. View source
  5. Malinda KM, Sidhu GS, Mani H, et al. Thymosin β4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-368. View source
RESEARCH STATUS

This compound continues to be investigated in preclinical and/or clinical research. Scientific understanding continues to evolve as additional studies are published.

RESEARCH DISCLAIMER

For laboratory research use only. This information summarizes published scientific literature for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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RESEARCH DISCLAIMER

All VELOR compounds are sold strictly for laboratory and research purposes only. They are not intended for human consumption, ingestion, or any food, drug, cosmetic, or therapeutic use. By purchasing, you confirm you are 21+ and a qualified researcher or research institution. Statements have not been evaluated by the FDA.

RECOVERY
TB-500
$50.00
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